Dominic Smethurst, MA, MBChB, MRCP, MFPM
Chief Medical Officer


Dr. Dominic Smethurst is the Chief Medical Officer of Bicycle Therapeutics.

Dom has over twenty years of experience working with leading pharmaceutical and biotechnology companies, clinical research institutions, and the UK’s National Health Service (NHS). He was most recently a medical consultant, advising biopharma companies on clinical development strategies and licensing projects. Prior to that, he served as Chief Medical Officer of Tusk Therapeutics, an immuno-oncology company acquired by Roche, where he oversaw development of antibodies targeting CD25 and CD137, among others. Previously, as Vice President Oncology and Global Therapeutic Area Lead at Icon, a global contract research organization, Dom executed clinical trials involving numerous novel cancer treatments, including CAR-T therapies. Before Icon, he held physician leadership roles at AstraZeneca, Amgen and Adaptimmune.

Dom is a Member of both the Royal College of Physicians and the Faculty of Pharmaceutical Medicine. He earned an MBChB with Distinction from Addenbrooke’s Clinical School Cambridge, as well as an MA from Christ’s College Cambridge.

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