Careers

Position: Principal Scientist/Associate Director, Immuno-Oncology
Reports to: VP, Oncology Research
Location: Lexington, MA

POSITION OVERVIEW

We are seeking a talented biologist with expertise in immuno-oncology. He or she will primarily be responsible for leading projects from discovery to pre-clinical development of Bicycles and Bicycle Drug Conjugates. The successful candidate will work closely with both the Biology and Chemistry teams in US and UK to organize and schedule project centric activities, review data and progress and drive to advance the immuno-oncology pipeline.

KEY RESPONSIBILITIES

• Lead and manage drug discovery programs in immuno-oncology
  • Become in-house scientific expert and liaison for discovery programs
  • Oversee and manage in-house and external activities to produce high quality results while meeting timelines
  • Responsible for managing external academic collaborators and CROs if needed
  • Contribute to internal and external non-clinical IND-enabling studies
  • Incorporate findings into study reports and regulatory documents
• Independently conceive and propose novel approaches for the use of Bicycles in immuno-oncology
• Serve on other internal project teams to provide his or her expertise when necessary
• Provide updates to different research committees and senior management.
• Represent Bicycle externally in scientific conferences and other key stakeholder presentations. Able to advance Bicycle’s representation as a premier emerging oncology/immuno-oncology company.

QUALIFICATIONS
The successful candidate must possess experience in leading and advancing a drug discovery program and in a bio-pharmaceutical company.

Key requirements include:

• A PhD or equivalent in immunology or immuno-oncology required
• 6+ years of industrial managerial experience. A record of accomplishment, including a proven track record in advancing drug discovery programs
• Preferably experience in development of tumor immunotherapy, especially in STING, RIG-I, inflammasome or toll-like receptor biology and/or experience in bispecific T cell activating molecules is high desirable
• Strong interpersonal skills, confident and experienced in presenting to wide variety of audiences including internal teams, collaborators, scientific audiences, senior management and partners.
• Ability to conduct research independently and project-manage distinct packages of work.
• Excellent organizational skills and ability to work flexibly and reliably, prioritizing accordingly to the company objectives
• Ability to travel domestically and internationally as needed
• Entrepreneurial, enjoys working in a fast-paced, small-company environment

Position: Research Scientist – Oncology
Reports to: Oncology Project Leader
Location: Lexington, MA

POSITION OVERVIEW

The Research Associate/Scientist located in Lexington, MA USA will be primarily responsible for developing oncology in vitro and ex vivo assays of bicyclic peptides (Bicycles®), Bicycle Toxin Conjugates, Bicycle Targeted Innate Immune Activators, and/or Bicycle T cell Modulators to enhance progress of Bicycle’s oncology pipeline towards the clinic. In this lab-based role, he or she will be a key player in implementing in vitro characterizations of these oncology programs in Cambridge, U.S.

KEY RESPONSIBILITIES

The successful applicant will have a strong scientific background and hands-on laboratory skills in oncology and/or immuno-oncology with experience of oncology and immunological assay development and in vitro pharmacology. The successful candidate will work as part of the Oncology laboratory team and will be responsible for designing, developing and running immunological and cell-based assays to characterize Bicycles, Bicycle Toxin Conjugates, Bicycle Targeted Innate Immune Activators, and/or Bicycle T cell Modulators. The role will involve close interaction with both the Biology and Chemistry teams in UK for project centric activities and for data and progress review. The successful candidate will be expected to possess innovative assay development expertise and expand our suite of assays and capabilities in-house as well as working closely with CROs to deliver key data to support the programs and to inform the pre-clinical development.

Tasks include:

• Independently design, conduct, interpret, troubleshoot and report in vitro studies using a wide range of established methodologies for Bicycles, Bicycle Toxin Conjugates, Bicycle Targeted Innate Immune Activators, and/or Bicycle T cell Modulators.
• Develop and implement a range of oncology, cell viability and cytotoxicity assays as required for new projects across a diverse range of target classes
• Develop and implement a range of immunological and cell-based assays, including functional T and NK cell assays, in vitro differentiation of immune cells.
• Identify, evaluate and implement new technologies to augment and extend in-house assay capabilities through literature and working closely with academic collaborators and CROs.
• Serve on internal project teams. Communicate with project team and colleagues effectively and work well with others to meet experimental and organizational goals.
• Present the results of independently conducted research effectively in oral or written form to line manager

QUALIFICATIONS

• M.S. with >3+ or Ph.D. with 0-3 year’s academic or industry experience in oncology and immune-oncology
• Broad experience in cell biology techniques and applications
• Candidates with specific experience of oncology and immune-oncology will be preferred
• Preferred experience in at least one of the areas below
  • Tumor cell proliferation and cytotoxicity, especially with toxin conjugates
  • Cellular immunological assays, including but not limited to T cell activation, mixed lymphocyte reaction, T and/or NK cell cytotoxicity
  • Multiple immune endpoints including cell proliferation/cytotoxicity/apoptosis, cytokine level, and cell surface molecule expression using cellular, biochemical, and flow cytometry techniques.
• Ability to conduct research independently and manage multiple tasks in parallel
• Excellent organizational skills and ability to work flexibly and reliably, prioritizing accordingly to the company objectives
• Team player who collaborates and communicates effectively in team environment
• Innovative, entrepreneurial, enjoys working in a fast-paced, small-company environment

HOW TO APPLY

Please send your cover letter and cv to careersUS@bicycletherapeutics.com with the job position referenced in the subject line.