With the rapidly growing threat of antimicrobial resistance, new anti-infective products are urgently needed. Bicycles are structurally similar to many of the commonly prescribed and highly effective antibiotics, making them ideal templates for the design of next generation antibacterial drugs. In 2018, Bicycle secured a grant from Innovate UK, the UK’s innovation agency tasked with partnering to drive the science and technology innovations that will grow the UK economy. This grant allows Bicycle to apply its technology to develop the next generation of antibiotics.
Bicycle secured additional funding in 2019 under a contract from the U.K. Department of Health and Social Care as part of the Small Business Research Initiative. Under the contract, Bicycle will identify Bicycle inhibitors to a range of Penicillin Binding Proteins (PBPs) from pathogens of significant medical concern and investigate their antimicrobial activity.