Bicycle is developing several molecules in the clinic, and advancing many additional discovery-stage projects.
Bicycles are a novel molecule formed by constraining short linear peptides into a stabilized bi-cyclic structure using a central chemical scaffold.
The resulting structure enables Bicycles to effectively mimic protein-protein interactions. Bicycles combine the pharmacological properties normally associated with a biologic with the pharmacokinetic and synthetic advantages of a small molecule.
Bicycles can be readily conjugated to other chemical payloads, or to other Bicycles:
- Bicycle Toxin Conjugates® contain a Bicycle targeted to a specific tumor antigen, a selectively cleavable linker, and a small molecule toxin payload
- Bicycle Radio Conjugates contain a Bicycle targeted to a specific tumor antigen, a selectively cleavable linker and a highly potent radioisotope
- Bicycles can be designed as immune cell agonists that are guided to the tumor under the direction of a tumor antigen targeting Bicycle