Bicycle Therapeutics - Publications

Publications

Publications

Presentations

2025

European Society for Medical Oncology (ESMO) Congress 2025

10.19.2025

NECTIN4 amplification (amp) as an actionable alteration in non-small cell lung cancer (NSCLC)

European Society for Medical Oncology (ESMO) Congress 2025

10.19.2025

A Phase 2 study of zelenectide pevedotin, a Bicycle® Drug Conjugate (BDC®), in patients with NECTIN4 amplified advanced breast...

European Association of Nuclear Medicine (EANM) 2025 Congress

10.08.2025

Preclinical Evaluation of MT1-MMP-Targeting Bicyclic Peptides for Radiotheranostic Applications

European Association of Nuclear Medicine (EANM) 2025 Congress

10.08.2025

First clinical experience with the bicyclic peptide radiotracer [68Ga]Ga-BCY25286 for PET/CT imaging of MT1-MMP in lung, urothelial and head...

2025 American Society for Clinical Oncology (ASCO) Annual Meeting

06.02.2025

Phase 1/2 Duravelo-1 study: Preliminary results of Nectin-4 targeting zelenectide pevedotin (BT8009) plus pembrolizumab in previously untreated, cisplatin-ineligible patients...

American Association for Cancer Research (AACR) Annual Meeting

04.29.2025

Development and clinical translation of a phage display-derived MT1-MMP-specific bicyclic peptide for radiotheranostic applications

European Lung Cancer Congress 2025

03.26.2025

Enhance anti-tumour activity of zelenctide pevedotin in non-small cell lung cancer (NSCLC) patients with NECTIN4 gene amplification

2024

2024 San Antonio Breast Cancer Symposium (SABCS)

12.12.2024

Enhanced anti-tumor activity of zelenectide pevedotin in triple negative breast cancer (TNBC) patients with NECTIN4 gene amplification

Society for Immunotherapy of Cancer (SITC)

11.07.2024

Mechanistic biomarker analyses following administration of BT7480, a novel Nectin-4/CD137 Bicycle tumor-targeted immune cell agonist®, in a Phase 1/2...

EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics

10.24.2024

Effects of Nectin-4 targeted Bicycle® Toxin Conjugate, zelenectide pevedotin (BT8009), and enfortumab vedotin on a human corneal tissue model

European Association of Nuclear Medicine (EANM) 2024 Congress

10.23.2024

Bicycle® Radionuclide Conjugates for radioisotope delivery to solid tumors

European Society For Medical Oncology (ESMO) Congress 2024

09.14.2024

EphA2-targeting Bicycle® Toxin Conjugate BT5528 in patients with advanced solid tumors: A Phase 1/2 study

European Society For Medical Oncology (ESMO) Congress 2024

09.14.2024

Initial results from a Phase 1/2 study of BT7480, a novel Nectin-4/CD137 Bicycle tumor-targeted immune cell agonist®, in patients...

European Society For Medical Oncology (ESMO) Congress 2024

09.14.2024

Peripheral neuropathy following treatment with Bicycle Toxin Conjugates® zelenectide pevedotin (formerly BT8009) or BT5528 monotherapy in patients with advanced...

European Society For Medical Oncology (ESMO) Congress 2024

09.14.2024

Zelenectide pevedotin (BT8009) monotherapy in enfortumab vedotin–naïve patients with metastatic urothelial carcinoma: Updated results of Duravelo-1

2024 American Society for Clinical Oncology (ASCO) Annual Meeting

06.02.2024

A phase 2/3 study of Bicycle Toxin Conjugate BT8009 targeting Nectin-4 in patients with locally advanced or metastatic urothelial...

2024 American Society for Clinical Oncology (ASCO) Annual Meeting

06.01.2024

Breaking from the paradigm of antibody-drug conjugates: Evaluation of clinical pharmacokinetics and safety of Bicycle Toxin Conjugates (BTCs)

American Association for Cancer Research (AACR) Annual Meeting

04.09.2024

Bicycle Toxin Conjugates® for the treatment of solid tumors

American Association for Cancer Research (AACR) Annual Meeting

04.09.2024

Tumor-targeted activation of CD137 using Bicycle® molecules: New insights into mechanism of action and discovery of BT7455, a clinical...

American Association for Cancer Research (AACR) Annual Meeting

04.08.2024

Modulation of the natural killer cell immune responseto tumor with a synthetic tumor-immune cell agonist, NK-TICA®

2023

ADC Target Selection Summit, Boston

12.06.2023

Bicycle Toxin Conjugates to Target Solid Tumors

SITC

11.07.2023

Discovery and evaluation of bicyclicpeptides as modulators of patternrecognition receptors

EORTC-NCI-AACR

10.13.2023

Characterization of Nectin-4 protein expression innon-small cell lung cancer patients

Structural Drug Design 2023

06.13.2023

Revitalising the antiviral arsenal: Bicycles as a new therapeutic modality

Antibody Engineering & Therapeutics Europe

06.12.2023

Bicycles – a modality for Tumor Targeted Immune Cell Agonism

NEMDMG

05.31.2023

Key DMPK Attributes of BT7480, a BicycleTumor-targeted Immune Cell Agonist Targeting™ Nectin-4 and Agonizing CD137

Bio-IT World

05.23.2023

Potent anti-tumor activity of a Lead-212 labelled MT1-MMP targeting Bicycle Radionuclide Conjugate™

BNA - International Festival of Neuroscience

04.26.2023

Bicyclic peptides (Bicycles) as novel multipurpose delivery systems

American Association for Cancer Research (AACR) Annual Meeting

04.18.2023

Phase 1/2 study of the safety, pharmacokinetics, and preliminary clinical activity of BT7480 in patients with Nectin-4 associated advanced...

American Association for Cancer Research (AACR) Annual Meeting

04.17.2023

Modulation of the natural killer (NK) cell immune response to tumor with novel synthetic tumor -immune cell agonist, NK-TICA™

American Association for Cancer Research (AACR) Annual Meeting

04.17.2023

EphA2-dependent CD137 agonism and anti-tumor efficacy by BT7455, a Bicycle tumor-targeted immune cell agonist®

American Association for Cancer Research (AACR) Annual Meeting

04.17.2023

Development of in vivo models for evaluation of NK-TICA™, novel Bicycle® tumor-targeted immune cell agonist® designed to engage NK cells

Innate Killer Summit

04.06.2023

Bicycles: Bispecific, Precision-guided NK Cell Activators for the Treatment of Solid Tumors

13th World ADC London

03.20.2023

Highlighting the Potential of Bicycle Conjugates to Target Solid Tumours

13th World ADC London

03.20.2023

Expanding the Potential of ADCs: Bicyclic Peptide (Bicycle®) Toxin Conjugates May Offer Advancements Over Traditional ADCs

TIDES Asia

03.15.2023

Bicycles – a new modality in the anti-viral armoury

UK Symposium: Advancing Drug Discovery for Oncology

03.13.2023

Bicycles as precision guided therapeutics

European Peptide Synthesis Conference 2023

03.07.2023

Synthesis of Bicycle® Peptides using Gold-mediated Cysteine Arylation

Next Generation Conjugates Summit 2023

02.27.2023

Bicycle Conjugates to Target Solid Tumors

ASCO Genitourinary (GU) Cancers Symposium Conference

02.17.2023

BT8009-100: A Phase I/II Study of Novel Bicyclic Peptide and MMAE Conjugate BT8009 in Patients (pts) with Advanced Malignancies...

MarketsandMarkets Biomarker and Companion Diagnostics Conference

02.15.2023

Turning preclinical findings into clinic-ready biomarker assays to support BT7480 development

2022

PEGS Europe

11.17.2022

Transferrin Receptor 1-targeting Bicycles: A New Platform for Transcytosis

Boulder Peptide Symposium

11.11.2022

Bicycles for precision guided delivery

SITC

11.10.2022

In-depth characterization of cDC1 ex vivo and in vitro models: development and comparison of conventional dendritic cell culture systems...

SITC

11.10.2022

Utility of humanized animal models for in vivo evaluation of NK-TICA®, novel Bicycle® tumor-targeted immune cell agonist® (Bicycle TICA®)...

SITC

11.10.2022

BT7455, a fully synthetic Bicycle tumor-targeted immune cell agonist®, leads to potent EphA2-dependent CD137 agonism and robust anti-tumor efficacy

SITC

11.10.2022

NKp46 engaging Bicycle NK-TICA® drives tumor targeted cytotoxicity

SITC

11.10.2022

Transcriptional profiling of Bicycle® tumor-targeted CD137 agonist-treated mouse tumors revealed an early and rapid activation of myeloid cells followed...

Festival of Biologics

11.07.2022

BT7480, a novel and fully synthetic Bicycle tumor-targeted immune cell agonist®

ACoP

11.03.2022

The application of PK/PD modelling in the clinical development of BT5528 – a novel toxin delivery platform

EORTC-NCI-AACR

10.26.2022

Establishment of an ex vivo tissue culture platform as a preclinical model to assess the mechanism of action of...

EORTC-NCI-AACR

10.26.2022

Development of a CD137 receptor occupancy assay to support the phase I/II study of BT7480, a Bicycle tumor-targeted immune...

ESCMID

10.11.2022

Characterisation of novel, non-covalent cyclic peptide (Bicycles®) inhibitors of PBP3s from important Gram-negative

ESCMID

10.11.2022

PBP inhibitors discovered using a modified phage display platform (Bicycles)

ESCMID

10.11.2022

Anti-Infectives Drug Discovery at Bicycle Therapeutics

Immuno UK

09.30.2022

Bicycle Therapeutics: Precision-guided immune agonism for the treatment of cancer

CICON

09.29.2022

BT7480, a synthetic Bicycle tumor-targeted immune cell agonist® (Bicycle TICA®), induces reprogramming of the tumor immune microenvironment through tumor...

World Clinical Biomarkers & CDx Summit

09.28.2022

Translating preclinical findings into clinical biomarker assays to support the Phase I/II study of BT7480, a Bicycle tumor-targeted immune...

ASCO

06.06.2022

A Combined Phase I/II Study of a Novel Bicycle Tumor-targeted Immune Cell Agonist® BT7480 in Patients with Nectin-4 Associated Advanced Malignancies

AACR

04.10.2022

BT8009-100 Phase I/II Study of Novel Bicyclic Peptide and MMAE Conjugate BT8009 in Patients with Advanced Malignancies Associated with...

AACR

04.08.2022

Modeling the cDC1 ex vivo and in vitro: Development and characterization of a conventional dendritic cell culture system for...

AACR

04.08.2022

Generation of a Bicycle NK-TICA™, a novel NK cell engaging molecule designed to induce targeted tumor cytotoxicity

AACR

04.08.2022

Activity of the erythropoietin-producing hepatocellular A2 receptor (EphA2) targeting Bicycle® Toxin Conjugate (BTC™) BCY6033 in EGFR inhibitor resistant non-small...

AACR

04.08.2022

Development of a CD137 receptor occupancy assay to support the phase I/II study of BT7480, a Bicycle® tumor-targeted immune cell...

Microbiology Society Annual Meeting

04.07.2022

Bicycle®: A novel therapeutic modality for SARS-CoV-2

2021

EuroTIDES

11.19.2021

Bicycles, bi-cyclic peptides, novel small molecule delivery systems for RNA therapeutics

SITC

11.12.2021

Quantitation of CD137 and Nectin-4 expression across multiple tumor types to support indication selection for BT7480, a Bicycle tumor-targeted immune cell...

SITC

11.12.2021

Establishing the preclinical/translational PK/PD relationship for BT7480, a Nectin-4/CD137 Bicycle tumor-targeted immune cell agonist™ (Bicycle TICA™)

SITC

11.12.2021

An integrative approach to optimize a synthetic EphA2-dependent CD137 agonist: Balancing potency, physiochemical properties, and pharmacokinetics to achieve robust...

SITC

11.12.2021

Generation of a Bicycle NK-TICA™, a novel NK cell engaging molecule designed to induce targeted tumor cytotoxicity

EORTC-NCI-AACR

10.07.2021

A first in class phase I/II study of the novel bicyclic peptide and MMAE conjugate, BT5528, in patients with...

ASCO

06.04.2021

A Combined Phase I/II Study of BT8009 a Novel Bicycle® Toxin Conjugate with MMAE in Patients with Advanced Malignancies with...

AACR

04.12.2021

BT7480, a novel Nectin-4 dependent agonist of the immune cell costimulatory receptor CD137

AACR

04.12.2021

Integrative surfaceome profiling identifies immunotherapeutic targets in osteosarcoma and preclinical testing of BT1769, an MT1-MMP-targeted Bicycle® toxin conjugate, in...

AACR

04.10.2021

Molecular-based enrichment strategy for Nectin-4 targeted Bicycle toxin conjugate BT8009

AACR

04.10.2021

Nectin-4-dependent immune cell stimulation and anti-tumor efficacy by BT7480, a Nectin-4/CD137 Bicycle® tumor-targeted immune cell agonist (TICA™)

AACR

04.10.2021

Microinjection of Nectin-4/CD137 tumor-targeted immune cell agonist (TICA™) activates the local tumor microenvironment

AACR

04.10.2021

A multi tumor survey of Nectin-4 expression to guide BT8009 indication selection

AACR

04.10.2021

Rapid Accumulation of Cytotoxic Payload in Tumor Tissue Drives BT5528 Activity in Tumor Models

2020

SITC

11.09.2020

EphA2/CD137 Bicycle® tumor-targeted immune cell agonists (TICAs™) induce tumor regressions, immunogenic memory, and reprogramming of the tumor immune microenvironment

SITC

11.09.2020

BT7480, a fully synthetic tumor-targeted immune cell agonist (TICA™) induces tumor localized CD137 agonism and modulation of tumor immune...

AACR Tumor Immunology & Immunotherapy

10.19.2020

BT7480, a novel fully synthetic tumor-targeted immune cell agonist (TICA™) induces tumor localized CD137 agonism

AACR Tumor Immunology & Immunotherapy

10.19.2020

Development of CD137 (4-1BB) receptor occupancy assay using fluorescently labeled Bicycles®

ESMO

09.17.2020

BT8009-100 Phase I/II Study of the Safety, Pharmacokinetics, & Preliminary Clinical Activity of BT8009 in Patients with Nectin-4 Expressing...

AACR

06.22.2020

A survey of EphA2 expression by immunohistochemistry (IHC) in tumor tissue microarrays (TMAs) to support BT5528 indication selection

AACR

06.22.2020

A novel fully synthetic dual targeted EphA2/CD137 Bicycle® peptide induces tumor localized CD137 agonist

AACR

06.22.2020

BT7480, a novel fully synthetic tumor-targeted immune cell agonist (TICA™) induces tumor localized CD137 agonist

ASCO

05.29.2020

BT5528-100 phase I/II study of the safety, pharmacokinetics, and preliminary clinical activity of BT5528 in patients with advanced malignancies...

2019

SITC

11.09.2019

A novel fully synthetic dual targeted EphA2/4-1BB Bicycle® peptide induces tumor localized 4-1BB agonism

SITC

11.09.2019

A novel fully synthetic dual targeted Nectin-4/4-1BB Bicycle® peptide induces tumor localized 4-1BB agonism

SITC

11.06.2019

A novel fully synthetic dual targeted Nectin-4/4-1BB Bicycle® peptide induces tumor localized 4-1BB agonism

EORTC-NCI-AACR

10.29.2019

BT8009, a Bicycle® Toxin Conjugate targeting Nectin-4, shows target selectivity, and efficacy in preclinical large and small tumor models.

EORTC-NCI-AACR

10.29.2019

BT5528, a Bicycle Toxin Conjugate targeting EphA2: mechanism of action and clinical translation

EORTC-NCI-AACR

10.27.2019

MT1-MMP Immunohistochemistry (IHC) analysis of tumor microarrays (TMAs) using a novel scoring system guides patient selection for BT1718 expansion...

World ADC Congress 2019

10.11.2019

BT5528, an EphA2-targeting Bicycle® Toxin Conjugate

ESMO

09.28.2019

Pharmacokinetic (PK) assessment of BT1718: A phase 1/2a study of BT1718, a first in class Bicycle Toxin Conjugate (BTC),...

30th Symposium on Medicinal Chemistry

05.02.2019

Bicycles® – An entirely new class of therapeutics

6th Annual Peptides Congress

04.25.2019

Activation of CD137 using multivalent and tumour targeted bicyclic peptides

ELRIG Research & Innovation

04.03.2019

Bicycles® – An entirely new class of therapeutics

AACR

04.02.2019

Activation of 4-1BB using multivalent and tumour targeted bicyclic peptides

AACR

04.02.2019

BT5528, an EphA2-targeting Bicycle Toxin Conjugate (BTC): Profound efficacy without bleeding and coagulation abnormalities in animal models

AACR

04.02.2019

BT8009: A bicyclic peptide toxin conjugate targeting Nectin-4 (PVRL4) displays efficacy in preclinical tumor models

9th Annual World ADC Conferene

03.06.2019

BT5528: A Bicycle Toxin Conjugate Targeting EphA2 for the Treatment of Solid Tumours

2018

EORTC

11.13.2018

Preliminary pharmacokinetic assessment of BT1718: Aphase I/IIatrial of BT1718 (a first in class Bicycle Toxin Conjugate) in patients with advanced...

EORTC

11.13.2018

BT5528, an EphA2-targeting Bicycle Toxin Conjugate (BTC): profound efficacy without bleeding and coagulation abnormalities in animal models

PEGS

11.12.2018

Novel Multimers of Bicyclic Peptides Cluster and Activate CD137 (4-1BB): A Costimulatory T-Cell Checkpoint Receptor

SITC

11.06.2018

Activation of the T cell costimulatory protein CD137 using multivalent bicyclic peptides

ELRIG Drug Discovery

10.09.2018

Novel Bicyclic Peptide Multimers Activate T Cell Costimulatory Protein CD137

ELRIG Drug Discovery

10.09.2018

Small Synthetic, Multivalent Bicyclic Peptides That Activate T Cell Costimulatory Protein CD137

NCRI

10.01.2018

A Cancer Research UK phase I/IIa trial of BT1718 (a first in class Bicycle Toxin Conjugate) given intravenously in...

35th European Peptide Symposium

08.01.2018

Small Synthetic, Multivalent Bicyclic Peptides That Activate T Cell Costimulatory Protein CD137

Promega Biologics

07.18.2018

Novel Bicyclic Peptide Multimers Activate T Cell Costimulatory Protein CD137

ASCO

06.05.2018

A Cancer Research UK phase I/IIatrial of BT1718 (a first in class Bicycle Toxin Conjugate) given intravenously in patients with...

AACR

04.14.2018

Small Synthetic, Multivalent Bicyclic Peptides That Activate T Cell Costimulatory Protein CD137

AACR

04.14.2018

Bicycle Toxin Conjugates (BTCs) targeting EphA2 for the treatment of solid tumours: Discovery and selection of BT5528

AACR

04.14.2018

BT5528, a Bicycle Toxin Conjugate (BTC) targeting EphA2 has potent anti-tumour activity without bleeding or coagulation abnormalities in animal models

2017

PEGS

04.30.2017

Bicyclic Peptides for Positron Emission Tomography (PET) Imaging of MT1-MMP Expressing tumours

PEGS

04.30.2017

The Bicycle platform: an efficient technology to generate high affinity, high selectivity molecules (Bicycles®) with unique drug like properties...

PEGS

04.30.2017

Discovery and development of BT1718, a novel bicyclic peptide-maytansinoid conjugate targeting MT1-MMP for the treatment of solid tumours: In vitro and in...

PEGS

04.30.2017

BT1718, a novel Bicycle Drug Conjugate® shows potent anti-tumor activity in diverse cell-derived and patient-derived tumor xenograft models

PEGS

04.30.2017

Identification of high affinity, highly selective bicyclic peptides (Bicycles®) to transmembrane proteins using phage display screening on whole cells

AACR

04.01.2017

Development of BT1718, a novel Bicycle Drug Conjugate for the treatment of lung cancer

AACR

04.01.2017

BT1718, a novel bicyclic peptide-maytansinoid conjugate targeting MT1-MMP for the treatment of solid tumours: Design of bicyclic peptide and...

AACR

04.01.2017

Bicyclic Peptides for Positron Emission Tomography (PET) Imaging of MT1-MMP Expressing Tumors

2012

2009

Publications

2025

Journal of Medicinal Chemistry

10.06.2025

High-Throughput Identification and Characterization of LptDE-Binding Bicycle Peptides Using Phage Display and Cryo-EM

Nature Communications Biology

05.28.2025

Discovery and chemical optimisation of a potent, bi-cyclic antimicrobial inhibitor of Escherichia coli PBP3

Nucleic Acids Research

04.10.2025

Conjugation to a transferrin receptor 1-binding bicycle peptide enhances ASO and siRNA potency in skeletal and cardiac muscles

bioRxiv

04.02.2025

Discovery and chemical optimisation of a potent, bi-cyclic (Bicycle®) antimicrobial inhibitor of Escherichia coli PBP3

ScienceDirect

03.10.2025

Rational design of cyclic peptides, with an emphasis on bicyclic peptides

bioRxiv

02.12.2025

Conditional activation of NK cell function using chemically synthetic constrained bicyclic peptides directed against NKp46 and tumor-expressed antigens

2024

Journal of Clinical Oncology

09.04.2024

Results from first-in-human phase I dose-escalation study of a novel Bicycle Toxin Conjugate targeting EphA2 (BT5528) in patients with...

Theranostics

08.06.2024

Development and preclinical characterization of a novel radiotheranostic EphA2-targeting bicyclic peptide

ACS Infectious Diseases

06.12.2024

Investigating penetration and antimicrobial activity of vector-Bicycle conjugates

Journal of Medicinal Chemistry

01.29.2024

Discovery and characterization of a bicyclic peptide (Bicycle) binder to thymic stromal lymphopoietin

2023

Bioanalysis

12.13.2023

Bioanalysis of the Bicycle® toxin conjugate BT5528 and released monomethyl auristatin E via liquid chromatography-tandem mass spectrometry

Journal of Medicinal Chemistry

07.11.2023

Structure-Guided Chemical Optimization of Bicyclic Peptide (Bicycle) Inhibitors of Angiotensin-Converting Enzyme 2

Nature Communications

06.16.2023

Multivalent bicyclic peptides are an effective antiviral modality that can potently inhibit SARS-CoV-2

2022

MDPI

11.18.2022

Antimicrobial and Cell-Penetrating Peptides: Understanding Penetration for the Design of Novel Conjugate Antibiotics

Journal of Medicinal Chemistry

10.10.2022

Discovery of BT8009: A Nectin‑4 Targeting Bicycle Toxin Conjugate for the Treatment of Cancer

Molecular Cancer Therapeutics

09.16.2022

BT8009; a Nectin-4 targeting Bicycle® Toxin Conjugate for treatment of solid tumors.

Bioconjugate Chemistry

08.02.2022

Gold-Mediated Multiple Cysteine Arylation for the Construction of Highly Constrained Bicycle Peptides

Journal of Medicinal Chemistry

07.12.2022

Discovery and Optimization of a Synthetic Class of Nectin-4-Targeted CD137 Agonists for Immuno-oncology

Molecular Cancer Therapeutics

06.08.2022

Comprehensive Surfaceome Profiling to Identify and Validate Novel Cell-Surface Targets in Osteosarcoma

2021

Journal for ImmunoTherapy of Cancer

11.02.2021

BT7480, a Novel Fully Synthetic Bicycle Tumor-Targeted Immune Cell Agonist™ (Bicycle TICA™) Induces Tumor Localized CD137 Agonism

Journal for ImmunoTherapy of Cancer

01.26.2021

Anticancer immunity induced by a synthetic tumor-targeted CD137 agonist

2020

ACS Infectious Diseases

08.18.2020

An Assay for Periplasm Entry Advances the Development of Chimeric Peptide Antibiotics

Molecular Cancer Therapeutics

05.12.2020

MMAE delivery using the Bicycle toxin conjugate BT5528

Journal of Medicinal Chemistry

03.30.2020

Identification and Optimization of EphA2-Selective Bicycles for Delivery of Cytotoxic Payloads

2019

AACR Journals

02.15.2019

Bicyclic Peptides as a New Modality for Imaging and Targeting of Proteins Overexpressed by Tumors

2018

ADMET

06.06.2018

Application of biomimetic HPLC to estimate lipophilicity, protein and phospholipid binding of potential peptide therapeutics

Journal of Medicinal Chemistry

03.08.2018

Stable and Long-Lasting, Novel Bicyclic Peptide Plasma Kallikrein Inhibitors for the Treatment of Diabetic Macular Edema

2017

2012

ChemMedChem

07.01.2012

Bicyclic Peptides with Optimized Ring Size Inhibit Human Plasma Kallikrein and its Orthologues While Sparing Paralogous Proteases

2009

Nature Chem Bio

05.31.2009

Publications

2025

NECTIN4 amplification (amp) as an actionable alteration in non-small cell lung cancer (NSCLC)

A Phase 2 study of zelenectide pevedotin, a Bicycle® Drug Conjugate (BDC®), in patients with NECTIN4 amplified advanced breast...

Preclinical Evaluation of MT1-MMP-Targeting Bicyclic Peptides for Radiotheranostic Applications

First clinical experience with the bicyclic peptide radiotracer [68Ga]Ga-BCY25286 for PET/CT imaging of MT1-MMP in lung, urothelial and head...

Phase 1/2 Duravelo-1 study: Preliminary results of Nectin-4 targeting zelenectide pevedotin (BT8009) plus pembrolizumab in previously untreated, cisplatin-ineligible patients...

Development and clinical translation of a phage display-derived MT1-MMP-specific bicyclic peptide for radiotheranostic applications

Enhance anti-tumour activity of zelenctide pevedotin in non-small cell lung cancer (NSCLC) patients with NECTIN4 gene amplification

2024

Enhanced anti-tumor activity of zelenectide pevedotin in triple negative breast cancer (TNBC) patients with NECTIN4 gene amplification

Mechanistic biomarker analyses following administration of BT7480, a novel Nectin-4/CD137 Bicycle tumor-targeted immune cell agonist®, in a Phase 1/2...

Effects of Nectin-4 targeted Bicycle® Toxin Conjugate, zelenectide pevedotin (BT8009), and enfortumab vedotin on a human corneal tissue model

Bicycle® Radionuclide Conjugates for radioisotope delivery to solid tumors

EphA2-targeting Bicycle® Toxin Conjugate BT5528 in patients with advanced solid tumors: A Phase 1/2 study

Initial results from a Phase 1/2 study of BT7480, a novel Nectin-4/CD137 Bicycle tumor-targeted immune cell agonist®, in patients...

Peripheral neuropathy following treatment with Bicycle Toxin Conjugates® zelenectide pevedotin (formerly BT8009) or BT5528 monotherapy in patients with advanced...

Zelenectide pevedotin (BT8009) monotherapy in enfortumab vedotin–naïve patients with metastatic urothelial carcinoma: Updated results of Duravelo-1

A phase 2/3 study of Bicycle Toxin Conjugate BT8009 targeting Nectin-4 in patients with locally advanced or metastatic urothelial...

Breaking from the paradigm of antibody-drug conjugates: Evaluation of clinical pharmacokinetics and safety of Bicycle Toxin Conjugates (BTCs)

Bicycle Toxin Conjugates® for the treatment of solid tumors

Tumor-targeted activation of CD137 using Bicycle® molecules: New insights into mechanism of action and discovery of BT7455, a clinical...

Modulation of the natural killer cell immune responseto tumor with a synthetic tumor-immune cell agonist, NK-TICA®

2023

Bicycle Toxin Conjugates to Target Solid Tumors

Discovery and evaluation of bicyclicpeptides as modulators of patternrecognition receptors

Characterization of Nectin-4 protein expression innon-small cell lung cancer patients

Revitalising the antiviral arsenal: Bicycles as a new therapeutic modality

Bicycles – a modality for Tumor Targeted Immune Cell Agonism

Key DMPK Attributes of BT7480, a BicycleTumor-targeted Immune Cell Agonist Targeting™ Nectin-4 and Agonizing CD137

Investigating soluble Nectin-4 and EphA2 as cancer biomarkers in plasma

Targeting Tumors with Bicycle Conjugates

NKp46 engaging Bicycle NK-TICA™ drives tumor targeted cytotoxicity

Potent anti-tumor activity of a Lead-212 labelled MT1-MMP targeting Bicycle Radionuclide Conjugate™

Bicyclic peptides (Bicycles) as novel multipurpose delivery systems

Phase 1/2 study of the safety, pharmacokinetics, and preliminary clinical activity of BT7480 in patients with Nectin-4 associated advanced...

Modulation of the natural killer (NK) cell immune response to tumor with novel synthetic tumor -immune cell agonist, NK-TICA™

EphA2-dependent CD137 agonism and anti-tumor efficacy by BT7455, a Bicycle tumor-targeted immune cell agonist®

Development of in vivo models for evaluation of NK-TICA™, novel Bicycle® tumor-targeted immune cell agonist® designed to engage NK cells

Bicycles: Bispecific, Precision-guided NK Cell Activators for the Treatment of Solid Tumors

Highlighting the Potential of Bicycle Conjugates to Target Solid Tumours

Expanding the Potential of ADCs: Bicyclic Peptide (Bicycle®) Toxin Conjugates May Offer Advancements Over Traditional ADCs

Bicycles – a new modality in the anti-viral armoury

Bicycles as precision guided therapeutics

Synthesis of Bicycle® Peptides using Gold-mediated Cysteine Arylation

Bicycle Conjugates to Target Solid Tumors

BT8009-100: A Phase I/II Study of Novel Bicyclic Peptide and MMAE Conjugate BT8009 in Patients (pts) with Advanced Malignancies...

Turning preclinical findings into clinic-ready biomarker assays to support BT7480 development

2022

Transferrin Receptor 1-targeting Bicycles: A New Platform for Transcytosis

Bicycles for precision guided delivery

In-depth characterization of cDC1 ex vivo and in vitro models: development and comparison of conventional dendritic cell culture systems...

Utility of humanized animal models for in vivo evaluation of NK-TICA®, novel Bicycle® tumor-targeted immune cell agonist® (Bicycle TICA®)...

BT7455, a fully synthetic Bicycle tumor-targeted immune cell agonist®, leads to potent EphA2-dependent CD137 agonism and robust anti-tumor efficacy

NKp46 engaging Bicycle NK-TICA® drives tumor targeted cytotoxicity

Transcriptional profiling of Bicycle® tumor-targeted CD137 agonist-treated mouse tumors revealed an early and rapid activation of myeloid cells followed...

BT7480, a novel and fully synthetic Bicycle tumor-targeted immune cell agonist®

The application of PK/PD modelling in the clinical development of BT5528 – a novel toxin delivery platform

Establishment of an ex vivo tissue culture platform as a preclinical model to assess the mechanism of action of...

Development of a CD137 receptor occupancy assay to support the phase I/II study of BT7480, a Bicycle tumor-targeted immune...

Characterisation of novel, non-covalent cyclic peptide (Bicycles®) inhibitors of PBP3s from important Gram-negative

PBP inhibitors discovered using a modified phage display platform (Bicycles)

Anti-Infectives Drug Discovery at Bicycle Therapeutics

Bicycle Therapeutics: Precision-guided immune agonism for the treatment of cancer

BT7480, a synthetic Bicycle tumor-targeted immune cell agonist® (Bicycle TICA®), induces reprogramming of the tumor immune microenvironment through tumor...

Translating preclinical findings into clinical biomarker assays to support the Phase I/II study of BT7480, a Bicycle tumor-targeted immune...

A Combined Phase I/II Study of a Novel Bicycle Tumor-targeted Immune Cell Agonist® BT7480 in Patients with Nectin-4 Associated Advanced Malignancies

BT8009-100 Phase I/II Study of Novel Bicyclic Peptide and MMAE Conjugate BT8009 in Patients with Advanced Malignancies Associated with...

Modeling the cDC1 ex vivo and in vitro: Development and characterization of a conventional dendritic cell culture system for...

Generation of a Bicycle NK-TICA™, a novel NK cell engaging molecule designed to induce targeted tumor cytotoxicity

Activity of the erythropoietin-producing hepatocellular A2 receptor (EphA2) targeting Bicycle® Toxin Conjugate (BTC™) BCY6033 in EGFR inhibitor resistant non-small...

Development of a CD137 receptor occupancy assay to support the phase I/II study of BT7480, a Bicycle® tumor-targeted immune cell...

Bicycle®: A novel therapeutic modality for SARS-CoV-2

2021

Bicycles, bi-cyclic peptides, novel small molecule delivery systems for RNA therapeutics

Quantitation of CD137 and Nectin-4 expression across multiple tumor types to support indication selection for BT7480, a Bicycle tumor-targeted immune cell...

Establishing the preclinical/translational PK/PD relationship for BT7480, a Nectin-4/CD137 Bicycle tumor-targeted immune cell agonist™ (Bicycle TICA™)

An integrative approach to optimize a synthetic EphA2-dependent CD137 agonist: Balancing potency, physiochemical properties, and pharmacokinetics to achieve robust...

Generation of a Bicycle NK-TICA™, a novel NK cell engaging molecule designed to induce targeted tumor cytotoxicity

A first in class phase I/II study of the novel bicyclic peptide and MMAE conjugate, BT5528, in patients with...

Nectin-4-dependent immune cell stimulation and anti-tumor efficacy by BT7480, a Nectin-4/CD137 Bicycle® tumor-targeted immune cell agonist (TICA™)