Publications
Learn about the research supporting our preclinical and clinical development programs
Publications
15 February 2019 Bicyclic Peptides as a New Modality for Imaging and Targeting of Proteins Overexpressed by Tumors
AACR Journals
8 March 2018 Stable and Long-Lasting, Novel Bicyclic Peptide Plasma Kallikrein Inhibitors for the Treatment of Diabetic Macular Edema
Journal of Medicinal Chemistry
1 July 2012 Bicyclic Peptides with Optimized Ring Size Inhibit Human Plasma Kallikrein and its Orthologues While Sparing Paralogous Proteases
CHEMMEDCHEM
31 May 2009 Phage-encoded combinatorial chemical libraries based on bicyclic peptides
Nature Chem Bio
Presentations
13 November 2018 Preliminary pharmacokinetic assessment of BT1718: Aphase I/IIatrial of BT1718 (a first in class Bicycle Toxin Conjugate) in patients with advanced solid tumours
EORTC
13 November 2018 Development of BT1718, a novel Bicycle Drug Conjugate for the treatment of cancer
EORTC
12 November 2018 Novel Multimers of Bicyclic Peptides Cluster and Activate CD137 (4-1BB): A Costimulatory T -Cell Checkpoint Receptor
PEGS
6 November 2018 Novel Multimers of Bicyclic Peptides Cluster and Activate CD137 (4-1BB): A Costimulatory T-Cell Checkpoint Receptor
SITC
9 October 2018 Novel Bicyclic Peptide Multimers Activate T Cell Costimulatory Protein CD137
ELRIG Drug Discovery
9 October 2018 Small Synthetic, Multivalent Bicyclic Peptides That Activate T Cell Costimulatory Protein CD137
ELRIG Drug Discovery
1 October 2018 A Cancer Research UK phase I/IIa trial of BT1718 (a first in class Bicycle Toxin Conjugate) given intravenously in patients with advanced solid tumours
NCRI
31 August 2018 Small Synthetic, Multivalent Bicyclic Peptides That Activate T Cell Costimulatory Protein CD137
35th European Peptide Symposium
18 July 2018 Novel Bicycle Peptide Multimers Activate T Cell Costimulatory Protein CD137
Promega Biologics
14 April 2018 Bicycle Toxin Conjugates (BTCs) targeting EphA2 for the treatment of solid tumours: Discovery and selection of BT5528
AACR
14 April 2018 BT5528, a Bicycle Toxin Conjugate (BTC) targeting EphA2 has potent anti-tumour activity without bleeding or coagulation abnormalities in animal models
AACR
14 April 2018 Small Synthetic, Multivalent Bicyclic Peptides That Activate T Cell Costimulatory Protein CD137
AACR
30 April 2017 Bicyclic Peptides for Positron Emission Tomography (PET) Imaging of MT1-MMP Expressing tumours
PEGS
30 April 2017 BT1718, a novel Bicycle Drug Conjugate® shows potent anti-tumor activity in diverse cell-derived and patient-derived tumor xenograft models
PEGS
30 April 2017 Identification of high affinity, highly selective bicyclic peptides (Bicycles®) to transmembrane proteins using phage display screening on whole cells
PEGS
1 April 2017 Bicycle Peptides for Positron Emission Tomography (PET) Imaging of MT1-MMP Expressing Tumors
AACR
1 April 2017 Development of BT1718, a novel Bicycle Drug Conjugate for the treatment of lung cancer
AACR
